DMSO reductase is a molybdenum-containing enzyme that catalyzes reduction of dimethyl sulfoxide (DMSO) to dimethyl sulfide (DMS). This enzyme serves as the terminal reductase under anaerobic conditions in some bacteria, with DMSO being the terminal electron acceptor.
The nature of dimethyl sulfoxide (DMSO, (CH 3) 2 SO) as a monodentate ligand is explored in this set of experiments. 1,2 DMSO can ligate metal atoms by bonding in one of two possible ways: through the oxygen atom or through the sulfur atom (Figure 1). The method of bonding in the complex can be determined with the use of infrared spectroscopy, and the nature of the ligand and its complexes can be explored using molecular modeling software from CAChe Scientific (see appendix of this manual).
Vapor-phase 2,2'-bipyridine will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 12.5 days. Particulate-phase 2,2'-bipyridine will be removed from the atmosphere by wet and dry deposition.
Acetylation regulates selective function of PXR independent of ligand activation. It was found that PCN- treated wild type hepatocytes showed much more intense Nile Red staining compared to the wild type hepatocytes treated with DMSO, suggesting increased lipogenesis or lipid accumulation in response to PXR ligand.
The oxygen atom in DMSO can interact with positive charges and thus stabilize metal cation. The sulfur atom, although somewhat positively charged, does not interact with negative charges effectively. Also, two methyl groups surround the sulfur atom and influence binding properties of DMSO.
ER ligand treatments were performed either in the presence of DMSO, the ubiquitin activating enzymes/E1 enzymes MLN7243 (1 μM), or the 26S proteasome inhibitor MG132 (10 μM). (D) qRT-PCR analysis of ESR1 and ESR2, from MCF7 and HCC1500 cells treated as in (C).
The FDA has approved DMSO as a prescription medication for treating symptoms of painful bladder syndrome. It's also used under medical supervision to treat several other conditions, including...
Several new Ru(III) compounds containing both DMSO and a heterocyclic dinitrogen ligand were synthesized. The crystal structures of the trans-[Ru(DMSO)(pz)Cl 4] − (pz = pyrazine) monoanion, an analogue to the anticancer complex NAMI, with two different cations, tetraphenylphosphonium and Na show very different architectures.
In DNA-ligand binding studies, the ligand can be a small molecule, ion, or protein which binds to the DNA double helix. The relationship between ligand and binding partner is a function of charge, hydrophobicity, and molecular structure.
A simple catalytic system, in which PdCl 2 is the sole metal catalyst and DMSO functions as an oxidant and solvent, enables a synthesis of dibenzothiophenes in high yields from 2-biphenylthiols. This transformation offers broad substrate scope and operational simplicity.
DFT allows a quantitative estimate of the global hardness and softness of a molecule. Thus, the preference for S- or O-DMSO bonding in a metal complex should be deduced from the calculation of the softness of the molecular fragment obtained by subtraction, from the parent complex, of the DMSO ligand.
O2 Absorption by Co(SALEN) in DMSO Accurately weigh out a sample of Co(salen) which has been finely ground (between 0.05 and 0.1 g) and place it in a side-arm test tube. Transfer DMSO (approximately 5 ml) to a small test tube that can fit inside the side-arm test tube and lower the tube carefully inside without spillage.
DMSO can function both as hard and soft base. If a metal bonds to the sulfur then it donates its electron from the PI orbital which increases the bond order and frequency, acting as a soft base. If the metal bonds through the oxygen then the bond is weaker.
The H 2 O molecule, coordinated trans to the S-DMSO ligand, is hydrogen bonded to the carboxylates of adjacent molecules (see Supporting Information for details). An IR spectrum of the solid Pd(S-DMSO)(OH 2)(TFA) 2 exhibits an absorption band at 1155 cm −1, consistent with S-coordination of DMSO (cf. Table 1).
Displacement of the η 6-arene ligand in cyclometalated ruthenium NHC complexes by DMSO selectively leads to a change from a facial to a meridional geometry. The DMSO complexes can serve as starting materials for the synthesis of more complex structures, e.g. by introducing bidentate ligands, as shown for 2,2′-bipyridine.
Dimethyl sulfoxide (DMSO) is widely used as a cosolvent to solubilize hydrophobic compounds in RNA-ligand binding assays. Although it is known that high concentrations of DMSO (>75%) can significantly affect RNA structure and folding energetics, a thorough analysis of how lower concentrations (<10%) of DMSO typically used in binding assays affects RNA structure and ligand binding has not been undertaken.
Lewis Acids and Bases Hard and Soft Acid/Base Theory. Definitions of Lewis Acid-Base Theory.Lewis acid/base theory (sometimes called donor-acceptor theory) is a broad, widely applicable approach to the classification of chemical substances and the analysis of chemical reactions.
Exposure to DMSO can significantly affect rolling interactions Figure 5 (A) illustrates the effect of DMSO exposure on rolling velocity. Irrespective of the exposure period, induced cells generally increase their rolling velocity as a function of fluid shear stress, similar to NT HL-60 cells.
A Theoretical Study of the Essential Role of DMSO as a Solvent/Ligand in the Pd(OAc) 2 /DMSO Catalyst System for Aerobic Oxidation. Wiktor Zierkiewicz; Timofei Privalov
Dimethyl sulfoxide (DMSO; (CH3)2SO) is an amphipathic molecule that has a highly polar domain and two apolar methyl groups, making it soluble in both aqueous and organic media . Although its biological effects have not been clearly defined, it is used extensively in a variety of fields.
The decreasing absorption at 686 nm as a function of ... a much stronger ligand than DMSO and displacement of the second DMSO is much more favorable than expulsion of the first DMSO ligand. ...
MSM and the corresponding sulfoxide, dimethyl sulfoxide ((CH 3) 2 SO, or DMSO), have different physical properties. MSM is a white crystalline solid at room temperature (m.p. = 109 °C) whereas DMSO is typically a liquid (m.p. = 19 °C). The sulfoxide is a highly polar aprotic solvent and is miscible with water; it is also an excellent ligand. MSM is less reactive than DMSO because the S-atom of the sulfone is already in its highest oxidation state (VI).
Background. Patients with X-linked hyper-IgM syndrome caused by CD40 ligand (CD40L) deficiency often present with episodic, cyclic, or chronic neutropenia, suggesting abnormal neutrophil development in the absence of CD40L-CD40 interaction.
In coordination chemistry, a ligand[help 1] is an ion or molecule that binds to a central metal atom to form a coordination complex. The bonding with the metal generally involves formal donation of one or more of the ligand's electron pairs. The nature of metal–ligand bonding can range from covalent to ionic. Furthermore, the metal–ligand bond order can range from one to three. Ligands are viewed as Lewis bases, although rare cases are known to involve Lewis acidic "ligands". Metals and ...
DMSO is commonly used in veterinary medicine as a liniment for horses, alone or in combination with other ingredients. In the latter case, often, the intended function of the DMSO is as a solvent, to carry the other ingredients across the skin. Also in horses, DMSO is used intravenously, again alone or in combination with other drugs.
Antibacterial activities (in vitro study) of Dimethylsulfoxide (DMSO) with and without of some ligand complexes of the transitional metal ions of ethyl coumarin were carried out with the help of agar well diffusion method technique against four human pathogenic bacteria isolation from burn and wound infections, Observed
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