Calcium citrate malate is a water-soluble calcium supplement. It is the calcium salt of citric acid and malic acid with variable composition. Calcium citrate malate's bioavailability stems from its water-solubility and its method of dissolution. When dissolved, it releases calcium ions and a calcium citrate complex.
Calcium absorption varies significantly depending on how it is formulated. Supplements providing 500 mg. of elemental calcium will provide calcium absorption as follows: Calcium Citrate/Malate (CCM) absorption rate 40%; calcium absorbed 200 mg; Calcium Carbonate absorption rate 26%; calcium absorbed 130 mg; Calcium Citrate absorption rate 22%
Comparative absorption of calcium sources and calcium citrate malate for the prevention of osteoporosis. Calcium citrate malate has high bioavailability and thus has been the subject of calcium studies in these populations. Positive effects have been seen in prepubertal girls, adolescents, and postmenopausal women.
Meta-analyses of calcium and bone mass studies demonstrate supplementation of 500 to 1500 mg calcium daily improves bone mass in adolescents, young adults, older men, and postmenopausal women. Calcium citrate malate has high bioavailability and thus has been the subject of calcium studies in these populations.
About 40% more calcium is absorbed from calcium citrate-malate compared to calcium carbonate or milk. Taking calcium in several smaller doses throughout the day as supplied in these tablets produces higher absorption than taking a larger dose all at once.
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