Caffeic acid phenethyl ester (CAPE), which is a potent inducer of heme oxygenase 1 (HO1), is a central active component of propolis, and the application of propolis improves periodontal status in...
Caffeic acid phenethyl ester inhibits HIV-1 integrase, and also inhibits proliferation of transformed cells. It induces apoptosis in transformed fibroblasts, and interferes with EGF signal transduction affecting both protein kinase C and ornithine decarboxylase activity.
CAPE protected dopaminergic neurons and alleviated methamphetamine-induced rotational behavior also in 6-hydroxydopamine hemi-parkinsonian mice, according to "Caffeic acid phenethyl ester protects nigral dopaminergic neurons via dual mechanisms involving heme oxygenase-1 and brain-derived neurotrophic factor" by Kurauchi Y, Hisatsune A, Isohama ...
Caffeic acid phenethyl ester (CAPE) is a natural bioactive compound. It occurs in many plants [ 1 ]. It is acquired from propolis obtained through extraction from honeybee hives [ 2 ]. The chemical name of CAPE is 2-phenylethyl (2E)-3-(3,4-dihydroxyphenyl)acrylate.
Caffeic Acid Phenethyl Ester is the phenethyl alcohol ester of caffeic acid and a bioactive component of honeybee hive propolis, with antineoplastic, cytoprotective and immunomodulating activities. Upon administration, caffeic acid phenethyl ester (CAPE) inhibits the activation of nuclear transcription factor NF-kappa B and may suppress p70S6K and Akt-driven signaling pathways.
Caffeic acid has also been detected in sweet potatoes, sunflower seeds and meal, soya beans, tobacco, spinach, apricots, coconut, and rolled oats(1). Caffeic acid is also found in coffee, fruit juices, and wine(1).
Twenty-one caffeic acid phenethyl ester (CAPE) derivatives were synthesized, and characterized by IR, HR-MS, 1 H and 13 C NMR analyses. All compounds were evaluated for their cytoprotective effects against H 2 O 2-induced cytotoxicity and neuritogenic activities in the neurite outgrowth in PC12 cells.
Caffeic acid phenethyl ester upregulates N‐myc downstream regulated gene 1 via ERK pathway to inhibit human oral cancer cell growth in vitro and in vivo Li‐Chuan Chung Department of General Education Center, Mackay Medicine, Nursing and Management College, New Taipei City, Taiwan
Database on Polyphenols in Foods. Showing all foods in which the polyphenol Caffeic acid is found Food Composition
Figure 1. Chemical structure of caffeic acid phenethyl ester. Figure 1. Chemical structure of ca eic acid phenethyl ester. 2.2. CAPE Suppresses UV-Induced MMP-1 Expression in Human Skin Tissues Next, we evaluated whether the e ect of CAPE could be recapitulated in human skin. We analyzed
Biosynthesis. Caffeic acid, which is unrelated to caffeine, is biosynthesized by hydroxylation of coumaroyl ester of quinic acid (esterified through a side chain alcohol). This hydroxylation produces the caffeic acid ester of shikimic acid, which converts to chlorogenic acid. It is the precursor to ferulic acid, coniferyl alcohol,...
A single dose of CAPE before DEN treatment reduced the appearance of tumors by 43%, according to "Cancer Prevention Mediated by Caffeic Acid Phenethyl Ester Involves Cyp2b1/2 Modulation in Hepatocarcinogenesis" by Beltrán-Ramírez O, Macías Pérez R, Sierra-Santoyo A, Villa-Treviño S.(1)
However, the molecular mechanisms for its antibacterial effects are unclear. Caffeic acid phenethyl ester (CAPE), an active component of propolis from honeybee hives (honeybee resin), has been reported to have anti‐inflammatory, anti‐carcinogenic and immunomodulatory properties (Grunberger et al., 1988).
This topic has 8 study abstracts on Caffeic acid phenethyl ester indicating that it may have therapeutic value in the treatment of Chemotherapy-Induced Toxicity, Cerebral Vasospasm, and Cardiotoxicity: Chemotherapy-Induced
Caffeic acid phenethyl ester (CAPE) is a natural phenolic chemical compound. It is the ester of caffeic acid and phenethyl alcohol. Natural occurrences. CAPE is found in a variety of plants. It is also a component of propolis from honeybee hives. Potential pharmacology
Parkinson's disease is associated with the loss of dopaminergic neurons in the substantia nigra and decreased striatal dopamine levels. We now report that caffeic acid phenethyl ester (CAPE), an active component of propolis, attenuated dopaminergic neurodegeneration and dopamine loss in the MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) mouse model of Parkinson's disease.
However, it can be found in other food sources such as apples, artichoke, berries, and pears. Wine also contains a significant amount of caffeic acid. Caffeic acid is used in supplements for boosting athletic performance, exercise-related fatigue, weight loss, cancer, HIV/AIDS, herpes, and other conditions.
Caffeic acid phenethyl ester (CAPE), a bioactive component of propolis, is considered as a new anti-cancer agent. Oral squamous cell carcinoma (OSCC) is the most common oral cancer with unsatisfying survival. N-myc downstream regulated family genes (NDRGs) involve in numerous physiological processes. We investigated the anti-cancer effect of ...
Caffeic acid phenethyl ester (CAPE) is a natural compound with anticancer activities but has low water solubility. In this work, sucrose fatty acid ester (SFAE) was used to nanoencapsulate CAPE in aqueous propylene glycol (PG) with a temperature-cycle method by heating at 90 °C for 20 min and cooling to 21 °C, followed by additional heating at 90 °C for 5 min and cooling to 21 °C.
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